Talk:Pancreatic lipase

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fairly concise portrait of pancreatic lipase with a lot of internal links ... any additions welcome - luke

Need some answers about pancreatic lipase

What is the average enzyme level of pancreatic lipase? What are the consequences of an extrmely high level of 3000 + , while there are no indications of pancreatic inflammation ?

The normal range for lipase is 22-51 and the median is 36.5. Because lipase is secreted from the pancreas as an active enzyme it is a consumer of fat as soon as it emerges without any interaction with other substances. The danger being that if large amounts remain resident in the pancreas, lipase can start to consume that organ's tissue leading to necrosis and permanent damage to the pancreas. This is by no means authoratative, simply information passed on by a one-time ideopathic acute pancreatitis attack sufferer.

Homerton (talk) 16:19, 12 February 2008 (UTC)

Looking for a cite

Can someone here find a ref for use at Trans fat? It is asserted there that human lipases don't act equally on both L- and D- isomers of industrially produced trans-fatty acids and that this is thought to explain why they have greater impact on atherosclerosis than the natural ones. It makes some sense, but there's a tag on it and no obvious source to cite. If someone here could please help out, it would be good.User:LeadSongDog come howl 16:41, 26 March 2010 (UTC)

"Phospholipase A2 removes fatty acid from carbon 2 of glycerol backbone of the phospholipid"; that is, pancreatic lipase breaks the triacylglycerol into 2 fatty acids and a 2-acyl glycerol and and phospholipase A2 finishes up the job by cleaving the 2-acyl glycerol thus creating the final products; 3 fatty acids and a glycerol