Talk:Spliceosome

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Spliceome listed on Wikipedia:Votes for deletion Feb 20 to Feb 26 2004, redirected to Spliceosome.

Untitled[edit]

Discussion pasted from vfd:

Spliceome - a freshly invented term, as far a I can tell. (44 google hits, of which most are misspellings of spliceosome or about a database named SpliceOme) Stewart Adcock 22:34, 20 Feb 2004 (UTC)
- I have heard it used in the bioinformatics literature. I suggest that spliceome redirect to spliceosome, and incorporate that material into a new section in spliceosome. --Lexor|Talk 23:41, 20 Feb 2004 (UTC)

-- Graham :) 21:05, 26 Feb 2004 (UTC)

- - My guess is, that spliceOme (like genOme/transcriptOme/proteOme...) is a collection of all splicing variants of all pre-mRNAs & mRNAs, and maybe even some other RNAs which are modified by the splicing reactions (like tRNA editing?). Kazkaskazkasako (talk) 11:13, 30 July 2009 (UTC)[reply]

LSm[edit]

The article lacks everything included in the LSm article. Who dares the courageous merge? --Ayacop (talk) 18:43, 13 April 2009 (UTC)[reply]

Type II introns[edit]

I have removed the following:

In 2008 new evidence derived from the first crystal structure of a group II intron suggested that the spliceosome is actually a ribozyme, and that it uses a two–metal ion mechanism for catalysis.^[1]

^ Toor N, Keating KS, Taylor SD, Pyle AM (April 2008). "Crystal structure of a self-spliced group II intron". Science. 320 (5872): 77–82. Bibcode:2008Sci...320...77T. doi:10.1126/science.1153803. PMC 4406475. PMID 18388288.

The intron in question is self-splicing, and may not comprise the spliceosome in its entirety.
Its not clear if the reverse transcriptase ORF is considered part of the ribozyme or not. (The ORF was replaced for the crystallisation, so is not discussed in the paper.)
The importance of this paragraph is in the evolutionary development of the spliceosome, so should be part of a progression in that context.

All the best: Rich Farmbrough, 20:40, 29 December 2019 (UTC).[reply]

[pmid18388288-1] Toor N, Keating KS, Taylor SD, Pyle AM (April 2008). "Crystal structure of a self-spliced group II intron". Science. 320 (5872): 77–82. Bibcode:2008Sci...320...77T. doi:10.1126/science.1153803. PMC 4406475. PMID 18388288.

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