Wikipedia:Articles for deletion/SSNRI

This page is an archive of the discussion about the proposed deletion of the article below. This page is no longer live. Further comments should be made on the article's talk page rather than here so that this page is preserved as an historic record.
The result of the debate was keep. Smoddy (Rabbit and pork) 21:44, 3 May 2005 (UTC)

SSNRI

I believe SNRI, rather than SSNRI, is the correct term

• Delete. It's an SNRI. Verified by the website of the manufacturer of Effexor: "Because EFFEXOR XR works on these two chemicals, it is known as an SNRI, or serotonin-norepinephrine reuptake inhibitor."Tobycat 02:09, 27 Apr 2005 (UTC)
• Redirect to SNRI. Meelar (talk) 03:04, Apr 27, 2005 (UTC)
• Redirect to SNRI. Megan1967 06:14, 27 Apr 2005 (UTC)
• Delete - Upon further examination I say Redirect to Serotonin-norepinephrine reuptake inhibitor not SNRI —Teknic^{Talk / Mail} 11:09, 27 Apr 2005 (UTC)
  • Sorry, but this is not the place to argue for that motion. And note that the page title will have the correct spellgni. Radiant_* 09:33, Apr 27, 2005 (UTC) no longer relevant. Radiant_* 11:39, Apr 27, 2005 (UTC)
• Strong Keep this describes Selective serotonin and norepinephrine reuptake inhibitor type anti-depressants I.e ( Venlafaxine et al). I've seen SSNRI used in research contexts. SNRI refers to drugs like Strattera (atomoxetine) that only inhibit norepinephrine reuptake. This is an important difference,they are not the same. Current research suggests that SNRI's lack much of the antidepressant activities of SSNRI drugs. Klonimus 07:20, 27 Apr 2005 (UTC)
  • You're confusing selective norepinephrine reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor. They share the same acronym, but from what I understand, SNRI is only commonly used to describe the latter, mostly because there are so few examples of the former. Unfortunately, a few have used it to describe drugs like Strattera, creating understandable confusion. It might be a good idea for someone to verify this, though.
    • Let me explain how this whole thing works, and maybe somone can do a web of redirects and disambigs. The key thing is that all these drugs are selective reuptake inhibitors compared to TCA antidepressants/typical antipsychotics which are not selective and have lots of side effects. Klonimus 02:58, 28 Apr 2005 (UTC)

SSRI Inhibits serotonin, anti-depressant. Zoloft, Prozac

SNRI Inhibits norepinephrine only, anti-ADHD. Before the marketing of Strattera, which is an SNRI, people used the term to refer to SSNRI drugs like Effexor that affect both serotonin and norepinephrine. This is wrong, and today that usage is deprecated. Right now, Strattera is the only SNRI on the market.

SSNRI refers to drugs like affect both serotonin and norepinephrine, anti depressant. Right now, Effexor and Cymbalta are the only SSNRI on the market in the US. Both are rather expensive, and not shown to be more effective than Zoloft which is going to off patent in 2006

Also serotonin-norepinephrine reuptake inhibitor should be moved to Selective serotonin norepinephrine reuptake inhibitor, since the selectivity is the major point. Selective_noradrenaline_reuptake_inhibitor needs to be merged with Selective norepinephrine reuptake inhibitor.

I've done a quick review of the literature, and the result is undecided.

1. SNRI is used to refer to both selective norepinephrine reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, the latter somewhat more than the former.

2. SSNRI always refers to selective serotonin-norepinephrine reuptake inhibitors

One of the problems is that SSNRI is not a terribly accurate term. Venlafaxine, for instance, is not selective; it also works on dopamine as well. I therefore think we should disambig SNRI, and redirect SSNRI to serotonin-norepinephrine reuptake inhibitor.

• Merge with SNRI. Klonimus's info is useful but since they are related and people are likely to confuse the two, they should be addressed in the same article. Radiant_* 09:33, Apr 27, 2005 (UTC)
• Keep as per Klonimus's distinctions.Capitalistroadster 00:12, 28 Apr 2005 (UTC)
• 'keep not really in favor of a merge Yuckfoo 16:44, 28 Apr 2005 (UTC)
• Keep, and thank Klonimus for the research. Kappa 00:16, 1 May 2005 (UTC)

This page is now preserved as an archive of the debate and, like some other VfD subpages, is no longer 'live'. Subsequent comments on the issue, the deletion, or the decision-making process should be placed on the relevant 'live' pages. Please do not edit this page.