Talk:Heroin

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Distinguished from black tar????[edit]

In the intro presently is" Medical grade diamorphine is used as a pure hydrochloride salt which is distinguished from black tar heroin,..." There are a lot of different street heroins available around the world and most are not "black tar"; they are powdered preparations.Generally white or brown powders. "Black tar heroin" is much too specific a description.

Thisarticle :Int J Drug Policy. 2009 May; 20(3): 277–282. Published online 2008 Oct 21. doi: 10.1016/j.drugpo.2008.08.003 PMCID: PMC2704563 NIHMSID: NIHMS94349 PMID: 18945606 Heroin in brown, black and white: Structural factors and medical consequences in the US heroin market Daniel Ciccarone*

might be an interesting place to start researching different forms.Cuvtixo (talk) 21:57, 17 April 2022 (UTC)[reply]

I am a student .
I am currently writing a student-writing: "Fried Hiroïn" (heated, half-chewed),

- effects, side effects, indication? (I'm usually a German speaker. Unfortunately , the topic in German is very suppressed . Contrary to English. With many thanks in advance.) Interessierter Benutzer (talk) 12:47, 27 April 2023 (UTC)[reply]

Semi-protected edit request on 17 March 2023[edit]

In the pharmacology section currently reading as “Once in the brain, it then is deacetylated variously into the inactive 3-monoacetylmorphine and the active 6-monoacetylmorphine (6-MAM), and then to morphine, which bind to μ-opioid receptors, resulting in the drug's euphoric, analgesic (pain relief), and anxiolytic (anti-anxiety) effects; heroin itself exhibits relatively low affinity for the μ receptor.[78]”

An addition on how 6-MAM is likely a more potent μ-opioid receptor agonist than morphine could be useful to explain why heroine is more potent than morphine

Dana E. Selley, Cheng-Chun Cao, Tammy Sexton, Jennifer A. Schwegel, Thomas J. Martin, Steven R. Childers, 2001, Biochemical Pharmacology, 62, 4, 447-455

From abstract: These results indicate that the heroin metabolite 6-MAM possesses higher efficacy than other heroin metabolites at μ-opioid receptors, which may contribute to the higher efficacy of heroin compared with morphine in certain behavioral paradigms in vivo. 129.12.157.174 (talk) 13:55, 17 March 2023 (UTC)[reply]

 Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Actualcpscm (talk) 15:13, 17 March 2023 (UTC)[reply]

Legal status in the province of British Columbia in Canada[edit]

Harm Reduction[edit]

A great amount of article space was devoted to discuss the general idea of Harm reduction. This article is not a place for this and it ought not be included except for what can be connected to heroin. I have boldly removed that section entirely as being only tangentially related. Graywalls (talk) 09:20, 11 October 2023 (UTC)[reply]

Heroin is also used in medical treatments, not only as a recreational drug. The description of the page should mention such. Instead of only saying it’s used for recreational use[edit]

Such as, "Pain medication and more commonly used as a recreational drug"

No other common opioids that are abused recreationally have this description on wikipefia Utaninja (talk) 13:09, 23 October 2023 (UTC)[reply]

There is a Medical Uses section, and non-recreational purposes are mentioned throughout, and the lead says more commonly as a recreational drug. I think that's almost certainly true, but if you can find a source saying it's more commonly used in a medical setting than recreationally, I'm sure that'd be welcomed. For a similarly structured article, i.e. a drug that is more commonly used recreationally than medically but does get some niche medical use, see methamphetamine. I think with other opioids, even heavily abused ones, they are more used medicinally than recreationally; also most other abused opioids are manufactured pharmaceutical drugs, and so at some stage require an intent for medical use (i.e. a prescription) to make their way onto the (black) market, whereas heroin sidesteps the pharmaceutical manufacturing step.
Kimen8 (talk) 13:28, 23 October 2023 (UTC)[reply]
That makes sense. Heroin is certainly used more recreationally than medically. Thanks for the explanation! This makes perfect sense. Utaninja (talk) 17:42, 8 November 2023 (UTC)[reply]